Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway |
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| Affiliation: | 1. Department of Breast Surgery, Liaoning Cancer Hospital & Institute, Shenyang 110042, China;2. Department of Infection, Liaoning Cancer Hospital & Institute, Shenyang 110042, China;3. Department of Endocrine Surgery, People’s Hospital of Liaoning Province, Shenyang 110016, China;4. School of Chinese Medicine, Hong Kong Baptist University, 999077, Hong Kong, China;1. Department of Otolaryngology, Changle People''s Hospital, Changle, 262400, China;2. Department of Stomatology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China;3. Department of Otolaryngology-Head and Neck Surgery, Shanghai First Peoples Hospital, Shanghai Jiaotong University, Shanghai, 200080, China;1. Nanjing University of Traditional Chinese Medicine, Nanjing 210000, China;2. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222000, China;3. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;1. Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;2. Cancer Science Institute of Singapore, National University of Singapore, Singapore;3. Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China;4. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China;5. Department of Anatomy, National University of Singapore, Singapore;6. Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;7. Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;8. State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;9. State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China;10. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;11. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China;1. Department of Medical Imaging, The Second Affiliated Hospital of Xi''an Jiaotong University, Xi’an, China;2. Department of Gastroenterology, The Second Affiliated Hospital of Xi''an Jiaotong University, Xi’an, China;3. Department of Neurology, The First Hospital of Xi’an, Xi’an, China;1. Hepatobiliary and Vascular Surgery, Liuzhou Municipal Liutie Central Hospital, Liuzhou, PR China;2. Hepatobiliary and Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China |
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| Abstract: | Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-1 reversed PF-inhibited proliferation and invasion, and knockdown of Notch-1 enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer. |
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| Keywords: | Paeoniflorin Breast cancer Proliferation Invasion Notch-1 |
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