Stellate ganglion blockade and verbal memory in midlife women: Evidence from a randomized trial |
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| Affiliation: | 1. Department of Psychiatry, University of Illinois at Chicago, Neuropsychiatric Institute, MC 913, 912 S. Wood St., Chicago, IL, 60612, USA;2. Department of Psychology, University of Illinois at Chicago, 1007 W. Harrison St., Chicago, IL, 60607, USA;3. Graduate Program in Neuroscience, University of Illinois at Chicago, Psychiatric Institute MC 912, 1601W. Taylor St., Chicago, IL, 60612, USA;4. Department of Obstetrics and Gynecology, Prentice Women’s Hospital, 250 E. Superior Street, Room 05-2174, Chicago, IL, 60611 USA;5. Department of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron Street, Suite 5-704 Chicago, IL, 60611 USA;1. Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA;2. Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN 55905, USA;1. Institute for Social and Preventive Medicine, Lausanne University Hospital, Switzerland;2. Division of General Internal Medicine, Mayo Clinic, Rochester, MI;3. Institute of Higher Education and Nursing Research, Lausanne University Hospital, Switzerland;4. Pain Center, Lausanne University Hospital, Switzerland;5. Department of Orthopedics, Lausanne University Hospital, Switzerland;6. Department of Psychiatry, Lausanne University Hospital, Switzerland;1. Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden;2. Department of Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden;3. Department of Plastic Surgery, Hand Surgery, and Burns, Linköping University, Linköping, Sweden;4. University of Twente, Enschede, Netherlands;1. University of Colorado Anschutz Medical Campus, USA;2. University of Pennsylvania School of Medicine, USA;1. Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland;2. Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland;3. Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland;4. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;5. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA;6. Johns Hopkins Center on Aging and Health, Baltimore, Maryland, USA |
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| Abstract: | ObjectivesIn a pilot randomized clinical trial of active stellate ganglion blockade (SGB) versus sham control, SGB significantly reduced the frequency of reported moderate to severe vasomotor symptoms (VMS) and the frequency of physiologic VMS measured using ambulatory skin conductance monitors. Here we examine secondary effects of SGB on verbal learning and memory.Study designIn a randomized, sham-controlled study, 36 women met eligibility criteria for cognitive assessments, of whom 17 were randomized to receive fluoroscopy-guided SGB and 19 to sham control.Main outcome measuresAt baseline and three months post-treatment, women completed tests of verbal learning and memory (primary outcome) and other cognitive measures and also wore an ambulatory monitor for 24 h to measure physiologic VMS and VMS reported in real time.ResultsVerbal learning improved following active SGB (p < 0.05) but not sham treatment; however, the interaction between group and time was not significant (p values 0.13-0.20). Two secondary cognitive measures improved only in the sham group. Improvements in physiologic VMS correlated significantly with improvements in verbal learning (r = 0.51, p < 0.05).ConclusionsSGB might confer benefits to memory in relation to the magnitude of improvement in physiologic VMS. Broadly these findings suggest a possible link between physiologic VMS and memory problems in midlife women. |
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| Keywords: | Menopause Vasomotor symptoms Memory Stellate ganglion blockade Hot flash |
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