Protective effect of vitamin E against ethanol-induced small intestine damage in rats |
| |
| Affiliation: | 1. Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;3. Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;4. Department of laboratory Medicine, Faculty of Paramedical sciences, shahidBeheshtiUniversity of Medical Sciences, Tehran, Iran;1. Department of Pediatric Surgery and Oncology, Medical University of Lodz;2. Department of Pathology, Medical University of Lodz;3. Department of Biochemistry, Medical University of Lodz;4. Department of Pediatric Surgery and Urology, Medical University of Gdańsk;1. Epidemiology Coordinating and Research Centre, University of Alberta, Edmonton, Alberta, Canada;2. Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada;1. Histology & Cell Biology Department, Faculty of Medicine, Zagazig University, Egypt;2. Histology Department, Faculty of Medicine, Taif University, Saudi Arabia;3. Pediatrics Department, Faculty of Medicine, Taif University, Saudi Arabia;1. Department of Andrology, Sexology & STDs, Faculty of Medicine, Cairo University, Cairo, Egypt;2. Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt;3. Department of Andrology, Sexology & STDs, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt;1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt;2. Department of Pharmacology, National Research Center, Giza, Egypt |
| |
| Abstract: | The role of oxidative stress and inflammatory reaction has been reported in various ethanol-induced complications. The purpose of this study was to evaluate the effect of ethanol-induced structural alteration, oxidative stress, and inflammatory reaction on the small intestine of rats, and plausible protective effect of vitamin E to determine whether it inhibits the abnormality induced by ethanol in the small intestine. Twenty-four male wistar rats were divided into three groups, namely: Control©, ethanol, and vitamin E treated ethanol groups.After six weeks of treatment, the small intestine length, villus height, crypt depth and muscular layer thickness, oxidative stress, and inflammatory parameters showed significant changes in the ethanol treated group compared to the control group. Vitamin E consumption along with ethanol ameliorated structural alteration of the small intestine and reduced the elevated amount of oxidative stress and inflammatory markers such as protein carbonyl, OX-LDL, IL-6, Hcy, and TNF-α. Furthermore, their total antioxidant capacity was increased significantly compared to that of the ethanol group. These findings indicate that ethanol induces the small intestine abnormality by oxidative and inflammatory stress, and that these effects can be alleviated by using vitamin E as an antioxidant and anti-inflammatory molecule. |
| |
| Keywords: | Ethanol Small intestine Rat Oxidative stress Vitamin E |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
