miR-663a inhibits hepatocellular carcinoma cell proliferation and invasion by targeting HMGA2 |
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Institution: | 1. Department of Pathophysiology, Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China;2. Institute of Immunology, School of Life Sciences, University of Science and Technology of China, 443 Huang-Shan Road, Hefei 230027, China;3. Department of Pathology, Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China;4. Experimental Animal Center, Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China |
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Abstract: | Hepatocellular carcinoma (HCC) is a highly aggressive solid malignancy throughout the world. Dysregulation of miRNAs play essential roles in HCC progression via aberrant regulation of cell proliferation, apoptosis, as well as metastasis. miR-663a is a poorly investigated miRNA. Whether miR-663a regulates HCC development remains unknown. The aim of the study was to explore the role of miR-663a in HCC development. To determine the expression level of miR-663a in HCC, we analyzed the data from GSE21362 and TCGA. The results showed that miR-663a was significantly down-regulated in HCC tissue compared with adjacent non-tumor tissue. Gain of function and loss of function assays revealed that miR-663a distinctly inhibited cell proliferation, migration and invasion. Mechanistic investigations demonstrated that miR-663a modulated cell functions through targeting and suppressing high mobility group A2 (HMGA2). In addition, overexpression of HMGA2 remarkably attenuated the tumor repressive effect of miR-663a. Taken together, miR-663a inhibits HCC cell proliferation and motility by targeting HMGA2. |
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Keywords: | Hepatocellular carcinoma miR-663a HMGA2 |
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