Differential effects of high and low strength magnetic fields on mouse embryonic development and vasculogenesis of embryonic stem cells |
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| Affiliation: | 1. University Heart Center, Clinic of Internal Medicine I, Department of Cardiology, Jena University Hospital, Jena, Germany;2. Department of Zoology, Faculty of Science, Tanta University, Tanta 31527, Egypt;3. Physics Department, Faculty of Science, Tanta University, 31527, Egypt;4. Department of Physiology, Justus Liebig University Giessen, Germany;1. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, United States;2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, United States;3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States;4. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, United States;5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States;6. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, United States;7. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States;1. Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan;2. Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan;1. Department of Obstetrics and Gynecology, Boston University School of Medicine/Boston Medical Center, 85 E. Concord St., 6th Floor, Boston, MA 02118, USA;2. Data Coordinating Center, Boston University School of Public Health, Fuller 9, 715 Albany Street, Boston MA 02118, USA;3. Department of Epidemiology, Boston University School of Public Health, Talbot 3E, 715 Albany Street, Boston, MA 02118, USA;1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China;2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China;1. Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;3. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China;4. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China;5. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Man-made magnetic fields (MFs) may exert adverse effects on mammalian embryonic development. Herein, we analysed the effect of 10 mT 50 Hz sinusoidal (AC) or static (DC) MFs versus 1 mT MFs on embryonic development of mice. Exposure for 20 days during gestation to 10 mT MFs increased resorptions and dead fetuses, decreased crown-rump length and fresh weight, reduced blood vessel differentiation and caused histological changes, accompanied with diminished vascular endothelial growth factor (VEGF) protein expression in several organs. In embryonic stem (ES) cell-derived embryoid bodies exposure towards 10 mT MFs increased reactive oxygen species (ROS), decreased vascular marker as well as VEGF expression and enhanced apoptosis. In conclusion, our combined data from in vivo and in vitro experiments identified VEGF as an important mediator during embryonic development that can be influenced by high strength MFs, which in consequence leads to severe abnormalities in fetus organs and blood vessel formation. |
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| Keywords: | Magnetic fields Embryonic development Embryonic stem cells VEGF |
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