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Application of nanoparticle technology in the treatment of Systemic lupus erythematous
Institution:1. Institut D’Investigacions Biomediques August Pi i Sunyer, Barcelona 08036, Spain;2. Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada;1. Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy;2. Center for Research in Molecular Medicine & Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain;1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE;2. Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE;3. Division of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE;4. Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA
Abstract:Systemic lupus erythematous (SLE) is a chronic heterogeneous multisystem autoimmune disease characterized by loss of tolerance to self-antigens and production of numerous autoantibodies. Current therapeutic approaches used to treat inflammatory autoimmune diseases are associated with debilitating side effects. In spite of significant advances in therapeutic options and increased understanding of the pathogenesis, novel therapeutic approaches are needed for treatment of SLE. Nanoparticle-based delivery systems that selectively deliver drugs to inflamed tissue or specific cell have the potential to improve drug delivery. This article reviews recent nanotechnology-based therapeutics strategies that are being developed for the treatment of SLE.
Keywords:Systemic lupus erythematous  Nanoparticles  Drug delivery  Treatment
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