| 豚鼠左室压力性心肌肥厚及心功能的改变 |
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| 引用本文： | 罗武生,郭兆贵.豚鼠左室压力性心肌肥厚及心功能的改变[J].中南大学学报(医学版),1988(1). |
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| 作者姓名： | 罗武生 郭兆贵 |
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| 作者单位： | 湖南医学院药理研究室
(罗武生)，湖南医学院药理研究室(郭兆贵) |
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| 摘 要： | 本文利用部分狭窄豚鼠升主动脉以增加左心后负荷,建立左室肥厚模型,观察了离体肥厚工作心脏心肌力学性能与泵功能的改变。结果表明,狭窄升主动脉70—75％,经35—40天即可造成左心室肥厚,术后65—70天肥厚充分建立。此时,肥厚心脏基础状态下的心功能较相应假手术心脏为低。我们可以认为,豚鼠左室肥厚模型结合工作心脏的实验方法,是全面评定左室肥厚心脏在基础状态下的心功能的一种较好的方法。
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| 关 键 词： | 心脏扩大 心脏功能试验 疾病模型 动物 豚鼠 |
PRESSURE OVERLOAD LEFT HEART VENTRICULAR HYPERTROPHY AND FUNCTIONAL ALTERATION IN GUINEA PIG |
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| Luo Wusheng Guo ZhaoguiResearch Section of Pharmacology.PRESSURE OVERLOAD LEFT HEART VENTRICULAR HYPERTROPHY AND FUNCTIONAL ALTERATION IN GUINEA PIG[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1988(1). |
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| Authors: | Luo Wusheng Guo ZhaoguiResearch Section of Pharmacology |
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| Institution: | Luo Wusheng Guo ZhaoguiResearch Section of Pharmacology |
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| Abstract: | Left ventricular hypertrophy was produced by constriction of the ascending aorta of the guinea pigs. Cardiac mechanic properties and pump functions were investigated on isolated,working heart preparations. The results showed that the hypertrophy can be induced 35-40 days after operation with 70-75% constriction of the aorta,and the hypertrophy became fully established 65-70 days after operation. Cardiac functions of the hypertrophied hearts 65-70 days after operation were depressed as compared with the sham-operated hearts. It is suggested that isolated working heart with experimental left ventricular hypertrophy may be an ideal method for evaluating the cardiac function alterations in cardiac hypertrophy. |
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| Keywords: | Heart enlargement Heart function tests Disease model animal Guinea pigs |
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