亚低温对创伤性脑损伤后FasL表达的影响

目的 探讨脑损伤后亚低温脑保护的作用机理。方法 以自由落体撞击法制伤脑损伤模型，采用免疫组织化学方法检测脑损伤及亚低温治疗后不同时间点的FasL蛋白表达。结果 脑损伤后1小时FasL表达开始增加，6小时增加最明显，72小时达高峰；亚低温治疗后FasL表达明显下降。结论 脑损伤后亚低温下降FasL表达而减少细胞死亡是其脑保护的作用机理之一。

Effects of moderate hypothermia on the expression of FasL following traumatic brain injury

Objective To study the neuroprotective mechanism of moderate hypothermia following traumatic brain injury.Methods A free-falling body device was used to produce traumatic brain injury. The expression of FasL was detected with immunohistochemistry method at different time points following traumatic brain injury.Results The expression of FasL began to increase at 1 hour, increased significantly at 6 hours and reached peak at 72 hours following brain injury; the expression of FasL was decreased significantly with treatment of moderate hypothermia.Conclusion It might be one of neuroprotective mechanism that moderate hypothermia downregulates the expression of FasL to reduce cell death.