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Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-κb signaling pathway with the anti-epidermal growth factor antibody IMC-C225
Authors:Guido M Sclabas MD  Shuichi Fujioka MD  PhD  Christian Schmidt PhD  Zhen Fan MD  Douglas B Evans MD  Paul J Chiao PhD
Institution:(1) Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, ISIS Holcombe Blvd., Box 107, 77030 Houston, TX;(2) Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas;(3) Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas;(4) Department of Visceral and Transplantation Surgery, The University of Bern, Inselspital, Bern, Switzerland
Abstract:
Keywords:Pancreatic cancer  epidermal growth factor receptor  NF-κ  B  bcl-xl  apoptosis
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