| 蛞蝓多糖抗鸭乙型肝炎病毒作用 |
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| 引用本文： | 蔡霞,陆启霞,刘群红.蛞蝓多糖抗鸭乙型肝炎病毒作用[J].中国基层医药,2009,16(4):581-582. |
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| 作者姓名： | 蔡霞 陆启霞 刘群红 |
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| 作者单位： | 1. 安徽理工大学医学院,安徽省淮南,232001
2. 淮南东方医院集团新庄孜医院药剂科 |
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| 基金项目： | 安徽省第一批重点科研项目 |
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| 摘 要： | 目的研究蛞蝓多糖抗鸭乙型肝炎病毒（DHBV）的作用。方法采用先天感染DHBV的北京雏鸭为模型，随机分设0．9％氯化钠注射液模型对照组、拉米夫定组、蛞蝓多糖低、中、高3个剂量组，每组8只雏鸭均以20mg·kg^-1·d^-1灌胃给药10d。斑点杂交法观察用药前与用药后5d、10d及停药后5d血清中DHBV-DNA表达。结果蛞蝓多糖不同剂量组对DHBV均有一定抑制作用。其中蛞蝓多糖的中、高剂量组于用药后第5天血清DHBV．DNA的吸光度A值为（0.66±0．14）、（0．73±0．26），第10天为（0．47±0．18）、（0．54±0．10），较0．9％氯化钠注射液对照组（1．61±0．54）、（1．20±0．51）明显降低。蛞蝓多糖的中、高剂量组对DHBV．DNA的抑制率于用药后第5天为24．14％、23．96％，第10天为45．98％、43．75％，与0．9％氯化钠注射液对照组相比明显提高。结论蛞蝓多糖具有降低血DHBV—DNA含量，抑制乙型肝炎病毒作用。
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| 关 键 词： | 海蛞蝓属 肝炎病毒 乙型 鸭 疾病模型 动物 |
Experimental study of limax polysaccharide on duck hepatitis B virus |
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| CAI Xia,LU Qi-xia,LIU Qun-hong.Experimental study of limax polysaccharide on duck hepatitis B virus[J].Chinese Journal of Primary Medicine and Pharmacy,2009,16(4):581-582. |
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| Authors: | CAI Xia LU Qi-xia LIU Qun-hong |
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| Institution: | CAI Xia, LU Qi-xia, LIU Qun-hong(School of Medicine ,Anhui University of Science ＆ Technology ,Huainan ,Anhui 232001, China) |
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| Abstract: | Objective To study the anti-duck hepatitis B virus (DHBV) action of limax polysaccharide. Methods 1-day old Beijing ducklings with congenital infection of DHBV were used as the animal model and were days. The expression of DHBV-DNA was detected by dot-blot hybridization test before treatment, five days and ten days after treatment. Results After medicated with Limax polysaccharide for five days and for ten days. The optic density value(OD value) of DHBV-DNA in ducklings serum were obviusly lower than that before treatment. There was significant difference between them. The inhibition rote of limax polysacchatide compared with the model group is markedly improved. Conclusion Limax polysaccharide can protect duck liver against inflammation by the inhibition of DHBV. |
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| Keywords: | Hermissends Hepatitis B virus uuck Disease models animal |
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