乳腺癌相关长链非编码RNA的研究进展

长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200 nt、不能编码蛋白质的RNA,参与基因调控的各个层面.近年来研究发现,多种lncRNA在乳腺癌的发生、发展过程中起着重要的调控作用.该研究就lncRNA在乳腺癌中的异常表达,与乳腺癌的增殖、凋亡、侵袭、转移的关系,以及在乳腺癌早期诊断、药物耐药、判断预后中的作用等相关进展做一综述,希望为乳腺癌的预测、诊断和个体化治疗提供新的靶点和思路.

Research progress of long non-coding RNA related to breast cancer

Long non-coding RNA (lncRNA) is a group of functional RNA molecules, which is more than 200 nu-cleotides in length, lacks ability of encoding protein and participates in all aspects of gene regulation. The current studies have indicated that some lncRNAs take part in regulating the process of breast cancer tumorigenesis and progression. This article reviewed the abnormal expression of lncRNA in breast cancer, its relationship to breast cancer growth, apoptosis, invasion and metastasis, and its function in early diagnosis, drug resistance and prognosis of breast cancer. This review was expected to offer an insight into a new target for the prediction, diagnosis and individual treatment of breast cancer.