急性脑梗死患者血清IL-35、MMP-9与颈动脉粥样硬化斑块稳定性的关系

目的探讨急性脑梗死患者血清白细胞介素-35(IL-35)、基质金属蛋白酶9(MMP-9)与颈动脉粥样硬化斑块稳定性的关系。方法选择急性脑梗死患者89例,应用彩色多普勒超声检查颈动脉斑块,根据颈动脉粥样硬化斑块稳定性分为易损斑块组和稳定斑块组。采用酶联免疫吸附法检测患者血清IL-35、MMP-9水平,并分析IL-35、MMP-9与斑块稳定性的关系。结果颈动脉粥样硬化易损斑块组的患者41例,稳定斑块组的患者48例。易损斑块组血清IL-35水平(17.89±7.21 ng/ml)明显高于稳定斑块组(9.08±3.45 ng/ml)(P<0.05)。MMP-9水平易损斑块组(430.36±72.78 ng/ml)亦显著高于稳定斑块组(305.16±45.63 ng/ml)(P<0.01),差异均有统计学意义。结论脑梗死患者血清IL-35、MMP-9水平可能与颈动脉斑块稳定性有关。

Relationship between the levels of serum IL-35,MMP-9 and the stability of carotid arteriosclerotic plaque in acute cerebral infarction

Objective To investigate the relationship between the levels of serum IL-35,MMP-9 and the stability of carotid arteriosclerotic plaque in acute cerebral infarction.Methods Carotid arteriosclerotic plaque was measured by color Doppler ultrasonography in 89 patients with acute cerebral infarction.They were divided into vulnerable plaque group and stable plaque group according to the carotid arteriosclerotic plaque stability.The serum levels of IL-35 and MMP-9 were measured by enzyme-linked immunosorbent assay.Results There were 41 cases in vulnerable plaque group and 49 cases in stable plaque group.The serum level of IL-35 in vulnerable plaque group(17.89±7.21 ng/ml)was significantly higher than that in stable plaque group(9.08±3.45 ng/ml)(P<0.05),and the serum level of MMP-9 in vulnerable plaque group(430.36±72.78 ng/ml)was significantly higher than that in stable plaque group(305.16±45.63 ng/ml)(P<0.01).Conclusion The serum level of IL-35、MMP-9 may be correlated with the stability of carotid arteriosclerotic plaque in acute cerebral infarction.