髓源性抑制细胞在构筑转移前微环境促肿瘤转移中的作用 |
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引用本文: | 魏华民.髓源性抑制细胞在构筑转移前微环境促肿瘤转移中的作用[J].中国癌症杂志,2017(6):516-520. |
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作者姓名: | 魏华民 |
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作者单位: | 首都医科大学附属北京友谊医院中医科,北京,100050 |
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基金项目: | 国家科技部重点领域创新团队(RA20134022),国家自然科学基金(81273718;81102719),中国中医科学院肿瘤扶正培本创新团队(YS1305) |
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摘 要: | 肿瘤细胞持续存活是肿瘤转移过程中的主要限速环节.与肿瘤微环境类似,转移前器官的局部微环境(转移前微环境)为肿瘤细胞的存活提供了适宜的环境,是肿瘤细胞在远端器官持续存活、增殖的重要条件.髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是这一环境中的关键成分,其构筑的促增殖、炎症、免疫抑制及血管重塑的转移前微环境在肿瘤细胞的种殖、转移灶的形成过程中具有重要作用,是抗肿瘤转移治疗的潜在靶点.该研究主要介绍MDSCs构筑转移前微环境的机制及相关信号通路,为干预转移前微环境的抗肿瘤转移研究提供参考.
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关 键 词: | 髓源性抑制细胞 转移前微环境 肿瘤转移 |
Role of myeloid-derived suppressor cells in premetastatic niche formation and tumor metastasis promotion |
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Abstract: | Sustaining survival of tumor cells is the main limiting step of tumor metastasis. Similar to tumor microenvironment, local environment in premetastatic organ (premetastatic niche) also provides a favorable condition for surviving of tumor cell and is the premise of tumor cell survival and proliferation in distant organ. Myeloid-derived suppressor cells (MDSCs) are the key component of the niche and play an important role in tumor cell implantation and metastasis formation through fabricating a proliferative, inflammatory, immunosuppressive and vascular remodeling premetastatic niche. MDSCs may also serve as potential therapeutic target for anti-metastasis therapy. Here, this study focused on the mechanisms of MDSCs in prematastatic niche formation and associated signal pathway, moreover, pro-vided reference to study on anti-metastasis therapy through interfering with the formation of premetastatic niche. |
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Keywords: | Myeloid-derived suppressor cells Premetastatic niche Tumor metastasis |
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