严重脑白质疏松症相关因素的病例对照研究

目的探讨严重脑白质疏松症的相关因素。方法按照筛选标准连续收集2015年4月-2016年2月武汉大学中南医院神经内科住院患者,通过头部核磁共振评估脑白质疏松症Fazekas评分并收集相关临床资料,并应用非条件Logistic回归来分析严重脑白质疏松症的相关因素。结果共纳入608例患者,包括Fazekas评分为0的对照组415例和Fazekas评分为3~6的病例组193例。多因素Logistic回归结果提示:高龄(G3 vs G1:OR10.81,95%CI 2.76~42.38,P=0.001;G4 vs G1:OR 28.40,95%CI 7.02~114.95,P0.05;G5 vs G1:OR 68.79,95%CI 14.22~332.92,P0.05)、脑动脉粥样硬化(OR 1.98,95%CI 1.07~3.65,P=0.029)和高血压病(OR=4.84,95%CI=2.65~8.85,P0.05)与严重脑白质疏松症之间呈显著正相关。结论高龄、脑动脉粥样硬化和高血压病可能是严重脑白质疏松症的独立危险因素。

A case-control study of related factors for severe leukoaraiosis

Objective To investigate the factors of the incidence of severe leukoaraiosis (LA).Methods According to the selection criteria,We enrolled the patients at Department of Neurology,Zhongnan Hospital of Wuhan University from April 2015 to February 2016.Fazekas scores were performed based on the brain magnetic resonance imaging (MRI) and relevant clinical data were collected.Logistic regression was used to analyze the relationships between relevant clinical factors and severe LA.Results 608 patients were finally enrolled including 415 controls with 0 Fazekas score and 193 cases with 3-6 Fazekas scores.The results of multivariate logistic regression indicated that advanced age (G3 vs G1:OR 10.81,95%CI 2.76~42.38,P=0.001;G4 vs G1:OR 28.40,95%CI 7.02~114.95,P<0.05;G5 vs G1:OR68.79,95%CI 14.22~332.92,P<0.05),cerebral artery stenosis(OR 1.98,95%CI 1.07~3.65,P=0.029) and hypertension(OR 4.84,95%CI 2.65~8.85,P<0.05) were significantly associated with the increased risk of severe LA.Conclusion Advanced age,cerebral artery stenosis and hypertension may be independent risk factors of severe LA incidence.