| The Study on the Correlation Between Plasma Adiponectin Level and Coronary Heart Disease |
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| 引用本文： | 张金国 杨娜 王学忠 宋光耀 高东升 魏广和 何华. The Study on the Correlation Between Plasma Adiponectin Level and Coronary Heart Disease[J]. 岭南心血管病杂志(英文版), 2005, 6(2): 85-89,105 |
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| 作者姓名： | 张金国 杨娜 王学忠 宋光耀 高东升 魏广和 何华 |
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| 作者单位： | [1]Department of Cardiology, The Affiliated Hospital of Jining Medieal College, Jining Shandong 272029, China [2]Departmentof Cardiology, Hebei Provincial People＇s Hospital, Shijiazhuang 050051, China |
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| 摘 要： | Objectives To investigate the relationship between plasma adiponectin level and coronary heart disease （CHD）, and some established cardiovascular risk factors and to probe its probable pathogenesis which adiponectin results in CHD. Methods The levels of plasma adiponectin, fasting plasma insulin （FINS）, C-reactive protein （CRP） and P-selectin were measured by ELISA, plasma ET-1 was measured by radioimmunoassay （RIA） in 75 male patients with CHD and 30 healthy male people. Body mass index （BMI）, waist / hip ratio （WHR） and insulin resistance index （Homa-IR） were calculated respectively. Results （1）The plasma adiponectin levels in CHD group were lower compared with control group[（5.18±2.57）mg / L vs（8.94±2.59）mg / L, P〈 0.001 ], there was no significant difference of plasma adiponectin levels in CHD sub-groups （P 〉 0.05）.（2） Based on multinominal stepwise logistic regression analysis, adiponectin was one of significant and independent risk factors for CHD. （3） Multivariate liner stepwise regression analysis showed that adiponectin had significant correlation with BMI and TG, BMI and TG were independent factors influencing on plasma adiponectin levels. （4） Pearson correlation analysis indicated plasma adiponectin levels were inversely related to FINS levels , Homa-IR, CRP, P-selectin and ET-1. Conclusions （ 1 ）Plasma adiponectin levels are lower in CHD patients compared the control subjects, there are no significant difference of plasma adiponectin levels in patients with SAP, UAP and AMI. （2） Plasma adiponectin levels are relative with CHD. Hypoadiponectinemia is an independent risk factor for CHD. （3）Established cardiovascular risk factors such as BMI and TG have an obvious influence on adiponectin. （4）The probable pathogenesis by which adiponectin involves in CHD is suggested that adiponectin relates to insulin resistance, inflammatory reaction and dysfunction of vessel endothelium.
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| 关 键 词： | 等离子体 冠心病 病理机制 治疗 |
The Study on the Correlation Between Plasma Adiponectin Level and Coronary Heart Disease |
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| Zhang JinGuo;Yang Na;Wang XueZhong;Song GuangYao;Gao DongSheng;Wei GuangHe;He Hua. The Study on the Correlation Between Plasma Adiponectin Level and Coronary Heart Disease[J]. South China Journal of Cardiology, 2005, 6(2): 85-89,105 |
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| Authors: | Zhang JinGuo Yang Na Wang XueZhong Song GuangYao Gao DongSheng Wei GuangHe He Hua |
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| Abstract: | |
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| Keywords: | Coronary atherosclerotic heart disease Adiponectin Risk factor Insulin resistance Inflammatory reaction Endothelial dysfunction |
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