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Numerical deconvolution by least squares: Use of polynomials to represent the input function |
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| Authors: | David J. Cutler |
| Affiliation: | (1) Department of Pharmaceutics, The School of Pharmacy, University of London, London WC 1, England |
| Abstract: | A new method for numerical deconvolution is described, for use in calculating drug input rates. The method is based on the least-squares criterion and approximates the input rate by a polynomial function. Ill-conditioning of the normal equations is avoided by using orthogonal functions. The use of the method is illustrated by means of examples, using simulated data. |
| Keywords: | numerical deconvolution linear systems analysis calculation of drug input rates calculation ofin vivo dissolution rates polynomials orthogonal functions leasts-quares fitting |
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