| 20(S)-原人参二醇组皂苷的制备及其转化制取人参皂苷Rh2 |
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| 引用本文： | 陈燕萍,孟勤,宋长春,马兴元,王广树,徐景达.20(S)-原人参二醇组皂苷的制备及其转化制取人参皂苷Rh2[J].中国药学杂志,1997(5). |
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| 作者姓名： | 陈燕萍 孟勤 宋长春 马兴元 王广树 徐景达 |
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| 作者单位： | 白求恩医科大学基础医学院 |
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| 摘 要： | 目的：制取２０（Ｓ）原人参二醇组皂苷并将其转化制备抗癌活性单体２０（Ｓ）人参皂苷Ｒｈ２。方法：以国产西洋参茎叶总皂苷为原料，通过萃取法制备２０（Ｓ）原人参二醇组皂苷；将２０（Ｓ）原人参二醇组皂苷碱催化水解后，经柱层析分离纯化制备２０（Ｓ）人参皂苷Ｒｈ２。结果：２０（Ｓ）原人参二醇组皂苷收率为４１．５％，其转化成２０（Ｓ）人参皂苷Ｒｈ２的转化率为９．６４％。结论：制取方法简便，收率较高。
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| 关 键 词： | 皂苷.西洋参 20（S）－原人参二醇组皂苷 20（S）－人参皂苷－Rh_2 |
Preparation of 20(S) protopanaxadiol saponins and 20(S) ginsenoside Rh 2 from 20(S) protopanaxadiol saponins |
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| Chen Yanping.Preparation of 20(S) protopanaxadiol saponins and 20(S) ginsenoside Rh 2 from 20(S) protopanaxadiol saponins[J].Chinese Pharmaceutical Journal,1997(5). |
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| Authors: | Chen Yanping |
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| Abstract: | OBJECTIVE: To prepare 20(S) protopanaxadiol saponins and change them into 20(S) ginsenoside Rh 2 having antitumor activity. METHODS: From the crude saponins of the stems and leaves of American ginseng grown in China, we prepared 20(S) protopanaxadiol saponins by extraction and 20(S) ginsenosiok Rh 2 by the alkaline hydrolysis of protopanaxadiol saponins and column chromatography. RESULTS: The yield of 20(S) protopanaxadiol saponins was 41.5%, and the yield of 20(S) ginsenoside Rh 2 was 9.64% from the 20(S) protopanaxadiol saponins.CONCLUSION: The method is simple and has a high yield. |
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| Keywords: | saponins American ginseng 20(S) protopanaxadiol saponins 20 (S) ginsenoside Rh 2 |
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