Electrocardiographic(EKG)Observation in 30 Volunteers Administered Gossypol

Ｅｌｅｃｔｒｏｃａｒｄｉｏｇｒａｐｈｉｃ（ＥＫＧ）Ｏｂｓｅｒｖａｔｉｏｎｉｎ３０ＶｏｌｕｎｔｅｅｒｓＡｄｍｉｎｉｓｔｅｒｅｄＧｏｓｓｙｐｏｌＨｕＣｈｅｎｇ－ｙｕｅ（胡承阅）ａｎｄＪｉａｎｇＣｈａｎ－ｈｕａ（蒋婵华）（ＡｎｈｕｉＩｎｓｔｉｔｕｔｅｏｆＰ...

Electrocardiographic(EKG)Observation in 30 Volunteers Administered Gossypol

To investigate the safety of gossypol in small doses,electrocardiograms(EKG)of 30 healthy male voluteers were traced at the 4th, 12th,36th and 52th weeks after administration of the drug. The dosage regimen was gossypol acetic acid, 15 mg per day,for the first 12 weeks(induction phase),followed by 10 mg or 7.5 mg for the rest 40 weeks(effective phase).Twelve voluteers were withdrawn due to hypokalemia,normal spermatogenesis in the effective phase or others before the 52th week.Wave form of all EKGs(96 groups obtained in the period)was normal.However,compared with EKG made before gossypol administration,in most cases the average of PR interval became longer and the average of QRS duration shorter. Subjects with PR interval prolongation, in the whole observation period, were more than those with PR interval reduction.The alteration of PR interval at the 4th and 12th week was statistically significant(P<0.05).The results were difficult to be explained with effect of gossypol on potassium metabolism.More extensive research is necessary to use gossypol,as a polyphenolic aldehyde compound for any clinical object.