Reversible decrease of dopamine D2 receptor density in the striatum of rats with acute hepatic failure |
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Authors: | Waśkiewicz J Freśko I Lenkiewicz A Albrecht J |
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Institution: | Laboratory of CNS Pathobiochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106, Warsaw, Poland. |
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Abstract: | The binding of a D2 receptor ligand, 3H]spiperone, was measured in striatal membranes derived from rats in which acute hepatic failure induced with thioacetamide (TAA) was associated with symptoms of hepatic encephalopathy (HE), and during recovery from HE. A 28% decrease of Bmax for the binding was measured in a symptomatic stage of HE, 1 day after TAA administration. The B(max) for 3H]spiperone binding was no longer different from control 7 days after TAA administration, when blood and brain biochemical correlates of HE were already absent. At 21 days after TAA administration, the B(max) was increased by 31% above the control level, consistent with other aspects of metabolic activation of the brain characteristic of the late recovery period from acute HE. |
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Keywords: | Acute hepatic failure Hepatic encephalopathy Thioacetamide Striatum Dopamine D2 receptors |
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