气相色谱法在手性药物分析中的应用进展

手性化合物作为特殊的物质群体,使用普通的分析方法往往很难实现对其进行定量或定性分析.气相色谱虽然只适用于易挥发且热稳定的化合物,但将气相色谱与质谱、手性固定相等联用或对手性化合物进行衍生以及特异性内标后,使用气相色谱对手性化合物进行分析依然能取得理想效果.对近年来气相色谱在手性分析中的应用和相关研究进展进行综述.

Progress of the application of gas chromatography in chiral drug analysis

Chiral compounds as a special group of substances, the use of ordinary analytical methods are often difficult to achieve its quantitative or qualitative analysis. Although gas chromatography is only applicable in the volatile and thermally stable compounds, gas chromatography with mass spectrometry and chiral stationary equal or chiral compounds were derived as well as specific internal standard using gas chromatography for analysis of chiral compounds is still able to achieve the desired effect. In this article, will have in recent years, gas chromatography in chiral analysis and related research progress are reviewed.