| 镁离子对心肌细胞内向整流钾离子流的影响 |
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| 引用本文： | 杨向军,蒋文平. 镁离子对心肌细胞内向整流钾离子流的影响[J]. 心电学杂志, 2002, 21(3): 146-148 |
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| 作者姓名： | 杨向军 蒋文平 |
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| 作者单位： | 215006,苏州大学附属第一医院心内科 |
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| 摘 要： | 目的：探讨镁离子对豚鼠心室肌细胞内向整流钾通道内向整流作用的影响。方法：应用膜片钳内面向外膜式记录并研究豚鼠心室肌细胞单通道内向整流性钾离子流。结果：在无镁离子浸浴液下,心室肌细胞内向整流性背景钾通道（Ik1)的内向整流作用不明显;当浸浴液含1mmol.L^-1镁离子时,Ik1出现明显的内向整流作用。结论：镁离子的存在是Ik1产生内向整流作用的必要条件。
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| 关 键 词： | 镁离子 心肌细胞 钾离子流 内向整流作用 电生理学 实验研究 |
| 修稿时间： | 2001-05-31 |
Effect of Mg 2 + on inward rectifier potassium channel in ventricular myocyte |
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| YANG Xiangjun,JIANG Wenping. Effect of Mg 2 + on inward rectifier potassium channel in ventricular myocyte[J]. Journal of Electrocardiology(China), 2002, 21(3): 146-148 |
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| Authors: | YANG Xiangjun JIANG Wenping |
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| Affiliation: | YANG Xiangjun,JIANG Wenping. Department of Cardiology,Affiliated Hospital No.1,Suzhou University,215006 |
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| Abstract: | Objective To study effects of Mg 2+ on inward rectifier potassium channel in guinea pig ventericular myocyte. Methods "Inside _ out"patch _ clamp technique was used to record single channel inward rectifier potassium channel. Results Inward rectifier characteristics of inward rectifier potassium channel current were weak when Mg 2+ was absent, whereas strong when Mg 2+ was present. Conclusion Mg 2+ was necessary for inward rectifier characteristics of inward rectifier potassium channel. |
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| Keywords: | Mg 2+ Patch clamp Inward rectifier |
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