急性低压缺氧对大鼠下消化道生长抑素分布的影响

目的 探讨急性低压缺氧对大鼠及溃疡模型大鼠下消化道生长抑素（ＳＳ）分布的影响及生理意义。方法３６只雄性Ｗｉｓｔｅｒ大鼠随机分成６组，其中３组为对照 ，３组为急性溃疡模型实验组。在低压内模拟上升至５００ｍ、１００００ｍ各停留３０ｍｉｎ，取消化道粘膜，用放免法测定胃肠道粘膜ＳＳ含量。结果 对照组小肠ＳＳ含量，５０００ｍ组明显高于地面组。对照组盲肠ＳＳ含量，５０００ｍ组明显高于１００００ｍ组和地面组，对

Effects of Acute Hypobaric Hypoxia on the Distribution of Somatostatin Contents in lower Gastrointestinal Tract of Rats

Objective To examine the effects of acute hypobaric hypoxia on the distribution of Somatostatin(SS) contains in lower gastrointestinal tract of rats. Method 36 Wister male rats were divided into 6 groups. Three were control groups, three were ulcerous groups. Each group contains ground, 5000 m above sea level and 10000 m above sea level. SS contents were determined with radioimmunoassy methods. Result Statistically significant difference was exhibited among each group.There was no significant difference of SS contents in each altitude between model and control. SS contents were significantly increased in intestine of control in 5000 m groups, in caecum in 5000 m groups, compared with that in ground (P<0.05). It was also significantly increased in intestine of model in 5000 m groups, in caecum in 5000 m groups, compared with that in ground (P<0.01). SS contents was significantly increased in caecum of model in 10000 m groups compared with that in ground (P<0.05). Except this, There was no significant difference of ss contents in lower gastrointestinal tract among each group. Conclusion SS contents in lower gastrointestinal tract were significantly increased in acute hypobaric hypoxia rats. This result suggested that ss contents in lower gastrointestinal tract may play an important protective role in acute hypobaric hypoxia rats.