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| 加味四逆散体外抗乙型肝炎病毒的实验研究 | |
| 引用本文： | 陈诗慧,郭卫真,刘妮,赵昉,卢焯明. 加味四逆散体外抗乙型肝炎病毒的实验研究[J]. 中华中医药学刊, 2006, 24(3): 478-479 |
| 作者姓名： | 陈诗慧 郭卫真 刘妮 赵昉 卢焯明 |
| 作者单位： | 1. 广州中医药大学热带医学研究所,广东,广州,510405 2. 广州中医药大学第一附属医院,广东,广州,510405 3. 广州市中医医院,广东,广州,510130 |
| 基金项目： | 广州中医药大学校科研和教改项目 |
| 摘 要： | 目的:研究加味四逆散体外抗乙型肝炎病毒(HBV)的作用。方法:通过加味四逆散作用于体外培养的2.2.15细胞株,观察其对细胞的毒性和对HBsAg和HBeAg分泌的抑制效果,以评价其抗HBV作用。结果:加味四逆散对2.2.15细胞的半数毒性浓度(TC50)为>200mg/mL;对2.2.15细胞分泌的HBsAg,HBeAg的半数抑制浓度(IC50)分别为<3.12mg/mL和43.68mg/mL;治疗指数(TI)分别为>64.12和>4.58。结论:加味四逆散在体外细胞培养中对HBsAg和HBeAg均有较强的抑制作用。 |
| 关 键 词： | 加味四逆散 2.2.15细胞株 |
| 文章编号： | 1009-5276(2006)03-0478-02 |
| 修稿时间： | 2005-09-28 |
In Vitro Experimental Study on the Effect of JIA WEI SINISAN Decoction Anti - Hepatitis B Virus |
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| CHEN Shi-hui,GUO Wei-zhen,LIU Ni,ZHAO Fang,LU Zhuo-ming. In Vitro Experimental Study on the Effect of JIA WEI SINISAN Decoction Anti - Hepatitis B Virus[J]. Chinese Archives of Traditional Chinese Medicine, 2006, 24(3): 478-479 | |
| Authors: | CHEN Shi-hui GUO Wei-zhen LIU Ni ZHAO Fang LU Zhuo-ming |
| Abstract: | Objective:To study the anti-HBV eftect of JIAWEISINISAN(JWSNS) decoction.Methods: In vitrocultured 2.2.15 cell lines was used in the experiment for observing the cytotoxicityand the effect of JWSNS decoction anti-HBV from inhibiting HBsAg and HBeAg excreted by 2.2.15 cell lines.Results: The TC_(50)of JWSNS decoction on 2.2.15 cell lines was >200mg/mL.The inhibitory rates of HBsAg and HBeAg excreted by 2.2.15 cell lines was IC_(50)<3.12mg/mL and 43.68mg/mL respectively.The therapeutic indexes(TI) was respectively >64.12 and >4.58.Conclusion: JIA WEI SINISAN decoction has obvious inhibitory effecton HBsAg and HBeAg byin vitrocultured cells. |
| Keywords: | HBsAg HBeAg |
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