| 甘草多糖的体内抑瘤作用及其机制的研究 |
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| 引用本文： | 王忱,谢广茹,史玉荣,张立华.甘草多糖的体内抑瘤作用及其机制的研究[J].临床肿瘤学杂志,2003,8(2):85-87. |
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| 作者姓名： | 王忱 谢广茹 史玉荣 张立华 |
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| 作者单位： | 1. 300060,天津,天津市肿瘤医院
2. 300060,天津,天津医科大学肿瘤研究所 |
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| 摘 要： | 目的：探讨甘草多糖对于S-180荷瘤小鼠体内肿瘤的抑制作用及其机制。方法：Balb/c小鼠接种S-180肉瘤瘤株后，分别给予甘草多糖和对照药物12天，然后处死。将荷瘤小鼠的肿瘤取出称重，并进行比较；免疫组织化学方法和HE染色对肿瘤中的bcl-2、p53和bax蛋白进行比较分析。结果：给予甘草多糖的小鼠的肿瘤明显小于对照组，而对照组的bcl-2和p53蛋白的表达率明显高于甘草多糖的小鼠组，bax蛋白的表达率则低于后。结论：甘草多糖对于S-180肿瘤具有抑制作用，并有可能影响bcl-2、p53及bax基因蛋白的表达。
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| 关 键 词： | 甘草多糖 S－180肉瘤 Bcl－2 Bax P53 |
| 文章编号： | 1009-0460(2003)02-0085-03 |
| 修稿时间： | 2002年4月5日 |
Study on the anti-tumor effect in vivo of Glycyrrhizia polyoaccharide and its mechanism |
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| Wang Chen,Shi Yurong,Xie Guangru,et al..Study on the anti-tumor effect in vivo of Glycyrrhizia polyoaccharide and its mechanism[J].Chinese Clinical Oncology,2003,8(2):85-87. |
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| Authors: | Wang Chen Shi Yurong Xie Guangru |
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| Institution: | Wang Chen,Shi Yurong,Xie Guangru,et al. Tianjin Cancer Institute,Tianjin 300060 |
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| Abstract: | Objective:To investigate the anti tumor effect of the Glycyrrhizia polysaccharide (GPS) and its mechanism.Methods:The S 180 tumor from mice was collected and the anti tumor rate calculated. The expression of Bax,Bcl 2 and P53 protein in the tumor tissue was studied by immuno histochemistry method.Results:The tumor of the B,C and D group was lighter than that of A group. The expression frequency of Bax,Bcl 2 and P53 protein differed significantly among the groups.Conclusion:The GPS can resist the mouse tumor, and it might be affect the expression of the Bax? Bcl-2 and P53. |
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| Keywords: | Glycyrrhizia polysaccharide S 180 sarcoma Bcl 2 Bax P53 |
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