| 颈动脉粥样硬化与非酒精性脂肪肝的胰岛素抵抗、脂联素异常相关机制及与中医证型关系分析 |
| |
| 引用本文： | 张毅,徐尚华.颈动脉粥样硬化与非酒精性脂肪肝的胰岛素抵抗、脂联素异常相关机制及与中医证型关系分析[J].广州中医药大学学报,2009,26(5):499-504. |
| |
| 作者姓名： | 张毅 徐尚华 |
| |
| 作者单位： | 福建省南平市第一医院心内科一区,福建南平,353000 |
| |
| 基金项目： | 福建省南平市科技局科研基金 |
| |
| 摘 要： | 目的]探讨颈动脉粥样硬化(CAS)与非酒精性脂肪肝(NAFLD)的相关机制--胰岛素抵抗(IR)、血清脂联素(APN)异常及与中医证型的关系.方法]筛选CAS伴NAFID(联合患病组)74例及单纯CAS(对照组)25例,分别测定其空腹血糖(FBG)、血清胰岛素(FI)、血清脂联素(APN),用自身稳态模型评估法(HOMA)评估IR、APN,并进一步在联合患病组进行指标间双变量相关分析;对比联合患病组各中医证型HOMA-IR、APN的差异并分析其辨证论治的参考指标.结果](1)联合患病组与对照组比较,HOMA-IR显著升高、APN显著降低(均P<0.01).(2)联合患病组的APN与HOMA.IR值呈显著负相关(γ=-0.447,P<0.01).(3)联合患病组的中医证型构成比不同,与湿热内蕴证组和痰瘀互结证组比较,脾虚痰湿证组的HOMA-IR显著升高、APN显著降低(均P<0.01).结论]CAS与NAFLD的相关机制显示IR、APN异常,可以认为NAFLD是动脉粥样硬化的一个新的危险因素;CAS与NAFLD的相关机制之间APN异常与IR存在关联.HOMA-IR、APN可作为CAS伴NAFLD中医辨证的参考,尤其对脾虚痰湿证辨证更具参考意义.
|
| 关 键 词： | 颈动脉粥样硬化/中医病机 非酒精性脂肪肝/中医病机 胰岛素抵抗 脂联素/血液 |
Pathogenic Mechanism Associated with Insulin Resistance and Adiponectin Abnormality in Carotid Atherosclerosis Patients Complicated with Nonalcoholic Fatty Liver Disease and Their Relationships with Traditional Chinese Medical Syndrome Types |
| |
| ZHANG Yi,XU Shanghua.Pathogenic Mechanism Associated with Insulin Resistance and Adiponectin Abnormality in Carotid Atherosclerosis Patients Complicated with Nonalcoholic Fatty Liver Disease and Their Relationships with Traditional Chinese Medical Syndrome Types[J].Journal of Guangzhou University of Traditional Chinese Medicine,2009,26(5):499-504. |
| |
| Authors: | ZHANG Yi XU Shanghua |
| |
| Abstract: | |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
