血竭总黄酮对实验性静脉血栓及体外血小板聚集的抑制作用

目的：观察血竭总黄酮对大鼠实验性静脉血栓形成及ADP、PAF诱导的大鼠和兔的血小板聚集的影响。方法：采用结扎大鼠腹主静脉造成的静脉血栓模型。结果：血竭总黄酮（160mg/kg,80mg/kg,40mg/kg）灌胃对大鼠实验性静脉血栓有明显的抑制作用（抑制百分率分别为73．53％，65．77％，39．75％），对ADP、PAF诱导的血小板聚集也有 明显抑制作用，并且呈剂量依赖关系。结论：血竭总黄酮具有明显的抑制静脉血栓形成及抗血小板聚集作用。

Effects of Flavone in Resina Draconis on platelet aggegation in rabbits and rats and experimental venous thrombosis in rats

To investigate the effects of Flavone in Resina Draconis (FRD) on platelet aggregation and experimental venous thrombosis in rats and rabbits. Methods: The venous thrombosis model and platelet aggregation induced by ADP or PAF in vitro were used. Results: The FRD at the dosage of 160mg/kg, 80mg/kg, 40mg/kg inhibited the experimental venous thrombosis by 73.53%, 65.77%, 39.75% respectively, and platelet aggregation induced by adnosine diphosphate (ADP) and platelet active foctor (PAF) with a dose-dependent manner in vitro. Conclusions: Result show FRD could significantely inhibit venous thrombosis and platelet aggregation.