前列腺特异性抗原升高与前列腺组织病理类型的关系

目的 探讨良恶性前列腺增生病理类型与血清fPSA和tPSA及其比值的关系.方法 分析有完整临床病理资料的前列腺增生疾病108例患者,均行PSA、盆腔MRI、前列腺穿刺活检检查.对比各病理类型之间的血清fPSA、tPSA及f/tPSA 比值,并进行统计学检验.结果 108例患者经病理证实前列腺癌25例（23%）,前列腺结节增生为83例,且分为间质性结节 7例（6%）、腺肌性结节24例（22%）、纤维腺瘤性结节5例（5 %）、腺性（腺瘤性）结节15例（14%）、混合性结节32例（30 %）.以上六组fPSA、tPSA比较差异均有统计学意义（P 〈0.05）;良、恶性前列腺增生f/tPSA比值比较差异有统计学意义;良性前列腺结节增生各型f/tPSA比值比较差异无显著性.结论 结合血清fPSA、tPSA及f/tPSA比值可提示前列腺增生病理类型,对临床治疗有指导意义.

Relationship between Elevated Prostate Specific Antigen and Prostate Tissue Pathological Type

Objective To explore the relationship between histological types of benign and malignant prostatic hyperplasia and serum fPSA and tPSA and their ratio. Methods Analysis of a complete clinical and pathological data of 108 cases of benign prostatic hyperplasia disease patients with PSA,pelvic MRl,prostate biopsy examination. Comparison between the various pathological types of serum fPSA,tPSA and f/tPSA ration,and conduct statistical tests. Results This group of 108 cases of patients with prostate cancer confirmed by pathology in 25 cases（23%）, prostatic nodular hyperplasia,83 cases are divided into interstitial nodules,7 cases（6%）,adenomyosis nodules in 24 patients（22%）,fibroadenoma nodules in 5 cases（5%）,glandular（adenomatous） nodules in 15 cases（14%）,mixed nodules in 32 cases（30%）.The above compared differences of six groups of fPSA,tPSA were statistically significant （P〈0.05）.Benign and malignant prostatic hyperplasia f/tPSA ratio was statistically significant.Benign prostatic nodular hyperplasia of various types of f/tPSA ratio has no significant difference. Conclusions Combination of serum fPSA,tPSA and f/tPSA ratio of benign prostatic hyperplasia may be prompted to pathological types,and clinical treatment guide.