A study on role of triiodothyronine (T3) hormone on the improvement of articular cartilage surface architecture |
| |
Authors: | Pei-tong Jia Xing-lin Zhang Hai-ning Zuo Xing Lu Peng-zhou Gai |
| |
Affiliation: | 1. Department of Orthopedics, Yantaishan Hospital, Yantai, 264000, China;2. Department of Joint Surgery, Yantai Yuhuangding Hospital, 264000, China |
| |
Abstract: | The present study was aimed to investigate the effect of triiodothyronine (T3) on the improvement of articular cartilage surface architecture at in vitro level. The T3 hormone was applied to neo-tissues in the range of 50, 100, 150 and 200 ng/ml for 5 weeks. At the end of the treatment, biochemical and histological evaluation was carried out in the neo-tissues. T3 hormone application significantly increased the collagen production in neo-cartilage tissues. The properties of tensile and compressive were significantly increased compared to the controls. However, T3 hormone application also induced hypertrophy. At the higher dose concentration of T3 hormone application, tensile and compressive properties were tremendously increased 4.3 and 4.6 fold respectively. Taking all these data together, it suggested that the T3 hormone application could be a potential agent to increase the functional properties such tensile and compressive in neo-tissues. |
| |
Keywords: | PTH Parathyroid hormone GAG Glycosaminoglycan T3 Triiodothyronine DMEM Dulbecco’s Modified Eagle Medium SD Standard Deviation Thyroid hormone Cartilage Tensile Compressive Neo-tissues |
本文献已被 ScienceDirect 等数据库收录! |
|