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Laboratory Assessment of the Anticoagulant Activity of Direct Oral Anticoagulants: A Systematic Review

Authors:	Bethany T. Samuelson Adam Cuker Deborah M. Siegal Mark Crowther David A. Garcia

Affiliation:	1. Department of Medicine, Division of Hematology, University of Washington, Seattle, WA;2. Department of Medicine and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;3. Department of Medicine, McMaster University, Hamilton, ON, Canada

Abstract:

Keywords:	antithrombotic therapy deep venous thrombosis direct oral anticoagulants laboratory pulmonary embolism AF atrial fibrillation APTT activated partial thromboplastin time CHEST American College of Chest Physicians DOAC direct oral anticoagulant DRVVT dilute Russell viper venom time ECT ecarin clotting time ETP endogenous thrombin potential ISTH International Society on Thrombosis and Haemostasis LC-MS/MS liquid chromatography/tandem mass spectrometry PiCT prothrombinase-induced clotting time PT/INR prothrombin time/international normalized ratio TEG thromboelastography TT thrombin time
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