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Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes |
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| Authors: | Santi Álvarez Sergi Mas Patricia Gassó Miquel Bernardo Eduard Parellada Amalia Lafuente |
| Affiliation: | 1. Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E‐08036 Barcelona, Spain;2. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain;4. Psychiatry Service, Hospital Clinic de Barcelona, Villarroel 170, E‐08036 Barcelona, Spain |
| Abstract: | We investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (MAO‐A VNTR; MAO‐A 941T>G; DAT VNTR; DAT ‐67A/T; CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*6) and the frequency of schizophrenia. Participants in the study were 242 subjects diagnosed with schizophrenia and related disorders and 290 hospital‐based controls. Genomic DNA was isolated from whole blood and genotyped by several methods. However, there was no association between schizophrenia and the alleles, genotypes or diplotypes that were studied or their interactions. Polymorphisms in genes coding for dopamine metabolism and transport enzymes did not predispose to or protect from schizophrenia and related disorders. |
| Keywords: | association studies genetic polymorphism Pharmacogenetics schizophrenia |