Association of polymorphisms in the BDNF,DRD1 and DRD3 genes with tobacco smoking in schizophrenia |
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| Authors: | Gabriela Novak Martha LeBlanc Clement Zai Sajid Shaikh Julien Renou Vincenzo DeLuca Natalie Bulgin James L. Kennedy Bernard Le Foll |
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| Affiliation: | 1. Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8;2. Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada;3. Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada;4. These authors provided a significant contribution.;5. Neurogenetics Section, Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, 250 College Street R‐30, Toronto, Ontario, Canada M5T 1R8;6. Departments of Family and Community Medicine, Pharmacology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Canada;7. Addiction Program, Centre for Addiction and Mental Health, Toronto, Canada |
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| Abstract: | Emerging evidence indicates that the DRD1‐BDNF‐DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour. |
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| Keywords: | Schizophrenia nicotine addiction dopamine polymorphism association gene genetic susceptibility association analysis BDNF DRD1 DRD3 smoking |
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