Distribution of HLA-A, -B and -DRB1 antigenic groups and haplotypes from the Brazilian bone marrow donor registry (REDOME) |
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| Authors: | Leandro Torres Luis Fernando da Silva Bouzas Alexandre Almada Luis Cristovão Moraes de Sobrino Porto Eliana Abdelhay |
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| Affiliation: | 1. Registro Brasileiro de Doadores Voluntários de Medula Óssea – REDOME, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil;2. Centro de Transplante de Medula Óssea, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil;3. Laboratório de Imunogenética, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil;4. Laboratório de Histocompatibilidade e Criopreservação, Universidade Estadual do Rio de Janeiro, UERJ, Rio de Janeiro, Brazil;5. Rede Brasil de Imunogenética, Rio de Janeiro, Brazil |
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| Abstract: | To improve assistance for patients awaiting a bone marrow transplant from an unrelated donor, it is important to genetically characterize the Brazilian volunteer bone marrow donors registry (REDOME). Our objective was to describe the antigenic groups and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 in the five regions of Brazil and by self-reported ethnicity groups using the REDOME data. Our study included 3,038,286 individuals. HLA antigenic groups and haplotype frequencies were estimated using an Expectation-Maximization (EM) algorithm. All described HLA-A*, HLA-B* and HLA-DRB1* groups were identified in this study. A*02 (25.9%), B*35 (11.8%) and DRB1*13 (13.4%) are the most frequent antigenic groups in REDOME, and the A*01-B*08-DRB1*03 haplotype is the most frequent in the registry. The antigenic group and haplotype frequency data obtained in this study could be helpful for national donor recruitment strategies across the country. |
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| Keywords: | Haplotype frequency estimation HLA haplotypes Donor registry Expectation-maximization Human leukocyte antigen Bone marrow transplant |
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