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O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
Authors:Xinghui Li  Wei Gong  Hao Wang  Tianliang Li  Kuldeep S. Attri  Robert E. Lewis  Andre C. Kalil  Fatema Bhinderwala  Robert Powers  Guowei Yin  Laura E. Herring  John M. Asara  Yu L. Lei  Xiaoyong Yang  Diego A. Rodriguez  Mao Yang  Douglas R. Green  Pankaj K. Singh  Haitao Wen
Affiliation:1. Department of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA;2. Department of Hepatobiliary Surgery and Liver Transplantation, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China;3. Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China;4. Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, NE 68198, USA;5. Department of Internal Medicine, Division of infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA;6. Department of Chemistry, Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, NE 68588, USA;7. Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;8. Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;9. Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA;10. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48105, USA;11. Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA;12. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Abstract:
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  • Keywords:OGT  RIPK3  necroptosis  inflammation  O-GlcNAc  HBP
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