Middle short gyrus of the insula implicated in speech production: Intracerebral electric stimulation of patients with epilepsy |
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Authors: | Afif Afif Lorella Minotti Philippe Kahane Dominique Hoffmann |
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Affiliation: | 1. Department of Neurosurgery, Neurological Hospital, Hospices Civils de Lyon, Lyon, France;2. Department of Anatomy, Lyon‐1 University, INSERM U 879, Lyon 1 University, Lyon, France;3. Neurology Department and INSERM U704, Grenoble University Hospital, Grenoble cedex 9, France;4. Department of Neurosurgery, Grenoble University Hospital, Grenoble cedex 9, France |
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Abstract: | Purpose: Different lines of evidence have suggested an involvement of the insular cortex in speech production. These have included results from lesion studies, functional imaging techniques, and electrical stimulation of the human insular cortex during invasive evaluation of epileptic patients. Methods: We evaluated 25 patients who had drug refractory focal epilepsy with at least one electrode stereotactically implanted in the insular cortex. Results: Eight responses to insular cortex electrical stimulation were reported by five patients as speech arrest (five responses) and a lowering of voice intensity (three responses). Conclusions: Data from this study implicate the middle short gyrus of the insula in the production of speech and show the importance of intrainsular electrode implantation during invasive pre‐resection evaluation by stereo‐electroencephalography (SEEG) when speech arrest occurs early in seizure semiology. |
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Keywords: | Insula Speech Epilepsy SEEG Electrical stimulation |
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