Evaluation of Cd8+ and natural killer cells defense in oral and oropharyngeal squamous cell carcinoma期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Evaluation of Cd8+ and natural killer cells defense in oral and oropharyngeal squamous cell carcinoma

Authors:	Edilmar Moura Santos Felipe Rodrigues de Matos Everton Freitas de Morais Hébel Cavalcanti Galvão Roseana de Almeida Freitas

Institution:	Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil

Abstract:	Purpose The aim of this study was to evaluate the population of CD8+ and natural killer (NK) cells in samples of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma. Patients and methods Fifty-four cases squamous cell carcinoma (42 OSCC and 12 OPSCC) were immunohistochemically treated by CD8 and CD57 monoclonal antibodies. It was evaluated the relationship of CD8+ and NK cells with tumor size, lymph node metastasis (LNM), clinical staging (CS), overall survival (OS) and disease-free survival (DFS). Results Only CD8 was higher expressed in both tumors T1 and T2 than T3 and T4, as well as in tumours without LNM and with CS II or III (P < 0.05). There was no association with OS and DFS of both biomarkers. Conclusions These findings suggest that the differential CD8+ cells infiltration in OSCC and OPSCC might reflect a distinctive tumor microenvironment with a favorable local cytotoxic immune response against neoplastic cells.

Keywords:	Squamous cell carcinoma Tumor immunity Natural killer cell CD8 cell
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