| 甲基汞对PC12细胞分化及活性的影响 |
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| 引用本文： | 李永进,毕晓颖,宋春梅,马洪波,王长文,李志超.甲基汞对PC12细胞分化及活性的影响[J].吉林医药学院学报,2005,26(4):187-189. |
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| 作者姓名： | 李永进 毕晓颖 宋春梅 马洪波 王长文 李志超 |
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| 作者单位： | 1. 吉林医药学院营养与食品卫生学教研室,吉林,吉林,132013
2. 吉林大学公共卫生学院卫生毒理学教研室,吉林,长春,130021 |
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| 摘 要： | 目的研究氯化甲基汞对PC12细胞活性和分化的影响。方法培养PC12细胞,用不同浓度的甲基汞作用于PC12细胞,用倒置显微镜观察细胞形态学变化,通过MTT检测PC12细胞活性。结果氯化甲基汞能抑制PC12细胞突起生长,降低细胞活性。结论氯化甲基汞可抑制PC12细胞分化和活性。
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| 关 键 词： | 甲基汞 PC12细胞 分化 活性 |
| 文章编号： | 1673-2995(2005)04-0187-03 |
| 修稿时间： | 2005年10月23 |
Effects of methylmercury on the differentiation and survival of PC12 cells |
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| LI Yong-jin,BI Xiao-ying,SONG Chun-mei,MA Hong-bo,WANG Chang-wen,LI Zhi-chao.Effects of methylmercury on the differentiation and survival of PC12 cells[J].Journal of Jilin Medical College,2005,26(4):187-189. |
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| Authors: | LI Yong-jin BI Xiao-ying SONG Chun-mei MA Hong-bo WANG Chang-wen LI Zhi-chao |
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| Abstract: | Objective To investigate the effects of methylmercury on the differentiation and surviva of PC12 cells. Methods Different concentration of methylmercury was used to culture PC12 cells. Morphological change was observed under invertphase contrastmicroscope,cell viability was evaluated via MTT. Results Results showed that methylmercury inhibited the neurite outgrowth and survival of PC12 cells. Conclusion Methylmercury can inhibit the differentiation and survival of PC12 cells. |
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| Keywords: | methylmercury PC12 cell differentiation survival |
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