| 乙型肝炎患者染色体分析 |
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| 引用本文： | 姜杰,孙淑清,吕彩霞,孙晓玲,王彬,王献理,金玉珂,蒋淑珍. 乙型肝炎患者染色体分析[J]. 吉林大学学报(医学版), 1992, 0(3) |
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| 作者姓名： | 姜杰 孙淑清 吕彩霞 孙晓玲 王彬 王献理 金玉珂 蒋淑珍 |
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| 作者单位： | 白求恩医科大学放射损伤临床教研室，白求恩医科大学放射损伤临床教研室，白求恩医科大学放射损伤临床教研室，白求恩医科大学放射损伤临床教研室，白求恩医科大学放射损伤临床教研室，白求恩医科大学放射损伤临床教研室，白求恩医科大学放射损伤临床教研室，吉林省卫生防病中心劳研所 |
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| 摘 要： | 本文用G显带方法对9名慢性乙型肝炎活动期患者的染色体进行分析,发现其染色体数目畸变率和结构畸变率都明显高于对照组。而结构畸变中的断裂点分布是非随机的,其中9号和11号染色体断裂点明显高于预期值,主要集中在9q11和11q13,而这些位点恰好和染色体脆性部位及癌基因座位有关。表明人体在乙型肝炎病毒(HBV)长期慢性感染下,可以产生各种类型的染色体畸变,而某些特定类型的染色体畸变可能是导致乙肝向肝癌转化的一个重要因素。
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| 关 键 词： | 乙型肝炎 淋巴细胞 染色体 G显带 |
A STUDY ON CHROMOSOMES IN PATIENTS WITH HEPATITIS B |
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| Jiang Jie,Sun Shuqing,Lu Caixia,. A STUDY ON CHROMOSOMES IN PATIENTS WITH HEPATITIS B[J]. Journal of Jilin University: Med Ed, 1992, 0(3) |
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| Authors: | Jiang Jie Sun Shuqing Lu Caixia |
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| Affiliation: | Department of Radiation Injury |
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| Abstract: | G - banded chromosome analysis was carried out in the peripheral lymphocytes collected from 9 patients with hepatitis B and 10 normal controls. The results showed that the frequencies of chromosomal structural aberration (8. 22%) and numerical aberration (18. 81 %) in the hepatitis group were significantly higher than those (1.66%, 5.46%) observed in the control group. The distribution of the breaking sites among chromosomes were non - randomized. The number of the breaking sites observed in chromosome 9 and chromosome 11 was higher than expected. These were mainly located at 9qll and Ilql3. The results indicated that patients with chronic hepatitis B viral infection might have various kinds of chromosomal aberrations, some of which may play an important role leading to hepatocellular carcinoma. |
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| Keywords: | Hepatitis B Peripheral lymphocyte Chromosome G -banding |
| 本文献已被 CNKI 等数据库收录！ |
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