巨噬细胞吞噬功能与食管癌发病关系的初步研究

本文报告用斑蝥乙醇浸出液皮肤发泡法获取巨噬细胞(Mφ)进行体外吞噬鸡红细胞试验,检查了郑州市健康者20人,入院待疗的食管癌(EC)患者37人及EC高发区鹤壁市郊食管上皮正常、轻增、重增、患癌志愿者101人的Mφ吞噬功能。结果表明EC患者的Mφ吞噬功能显著降低(P<0.001)。EC高发区人群Mφ吞噬功能较低。EC发生进程中Mφ吞噬功能逐渐降低。提示Mφ吞噬功能降低可能是EC的发病因素之一。因此努力提高机体Mφ的吞噬功能可能是EC发病学预防的重要措施之一。

A PRELIMINARY STUDY ON THE RELATION BETWEEN THE PHAGOCYTOSIS OF THE MACROPHAGES AND THE INCIDENCE OF ESOPHAGEAL CANCER

This paper reports the relation between the macrophage phagocytosis (Mp) and esophageal cancer (EC) found through the in vitro test of chicken red cells swallowed by the macrophages that were obtained from skin blistering arising from the cantherides alcohol infusion. Test results showed that gradual decrease (P0.001) of MP was seen in 48 volunteers with normal esophageal epithelium, 20 subjects with mild dysplastic epithelium, 29 subjects with severe dysplastic epithelium and 4 EC patients from the suburbs of He Bi City, an EC high incidence area in Henan; and that the MP of 37 EC patients of Henan Tumour Hospital was lower than MP of 20 healthy normal subjects (P0.001) flying in Zhengzhon. These results suggest that the lowering of MP may be one of the contributing factors in the incidence of EC. Thus one of the important measures for the prevention of this malignant tumour lies in making efforts to raise the MP of the body.