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| 60COγ-射线对鼠脑甲氨喋呤通透性的影响 | |
| 引用本文： | 孙伟建,黄如衡.60COγ-射线对鼠脑甲氨喋呤通透性的影响[J].肿瘤防治研究,1991,18(3):136-138. |
| 作者姓名： | 孙伟建 黄如衡 |
| 作者单位： | 1 军事医学科学院附属医院; 2 军事医学科学院毒物药物研究所; 3 解放军总医院神经外科 |
| 摘 要： | 小鼠头部接受不同剂量60Coγ射线照射后24小时,腹腔注射甲氨喋呤(10mg/kg),半小时后处死动物,采用磷光分析法测定血及脑组织中药物浓度。结果表明单次≥20Gy剂量的照射可使药物入脑浓度显著升高;分割照射亦可不同程度的提高药物的入脑浓度;照射前30分钟给予血卟啉衍化物能增强照射对脑药通透性的影响。 |
| 关 键 词： | 钴60 γ射线 甲氨喋呤 通透性 |
THE EFFECT OF~(60)Coγ RAY ON BRAIN PERMEABILITY TO METHOTREXATE IN MICE |
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| Sun Weijian,et al.THE EFFECT OF~(60)Coγ RAY ON BRAIN PERMEABILITY TO METHOTREXATE IN MICE[J].Cancer Research on Prevention and Treatment,1991,18(3):136-138. | |
| Authors: | Sun Weijian |
| Abstract: | This study was designed to evaluate the effects of irradiation on the peameability of mice brain to methotrexate (MTX). MTX was administered by intraperitoneal injection (10mg/kg) to unirradiated mice, and to mice receiving varying doses of cranial irradiation. 30 minutes after injection, MTX concentrations in brain and in blood were detected using phospho reseence method. There was a significant increase of MTX level in brain tissue after a single dose irradiatiOn (≥20Gy). Fractionated irradiation also increased MTX level in brain tissue. The effect of irradiation on brain drug permeability could be enhanced by hematoporphyrin derivative (HPD) given 30 minutes before irradiation. |
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