鼻咽癌高发家族外周血淋巴细胞染色体畸变的研究

本实验采用低叶酸培养条件,对一个鼻咽癌高发家族成员和配对的正常人作了染色体畸变研究。结果:家族血缘亲属组和对照组染色体畸变率(CAR)分别为11.01％和5.06％,两者比较有高度显著性差异(P<0.001);配偶组CAR为4.6％。与对照组比较无显著性差异(P>0.25);家族中一非癌成员发现t(7;14)(P22;q22)2次,与文献报告在2例鼻咽癌患者外周血发现的染色体易位完全相同。文章讨论了染色体畸变与鼻咽癌遗传易感性的关系,认为特殊的培养条件可使家族成员CAR与正常人之间的差距加大。

A STUDY OF A "HIGH RISK" NASOPHARYNGEAL cANCER FAMILY FOR THE CHROMOSOME ABERRATIONS

A "high risk" nasopharyngeal cancer family was studied for the chromosome aberrations by peripheral lymphocyte culture with TC 199 medium of low folic acid and G—banding technique. The average chromosome aberration rates (CAR) of the family and the control group were 11.1% and 5.06% respectively, there is a highly significant difference between them (P0.001). The CAR of spouse group was 4.6%, no statistical difference as compared with the control one (P0.25). The translocation (7; 14) (p22; q22) was observed twice in the non-affected member of the family. The data Obtained suggest. 1. some members in the family have an increased chromosome instablity, possibly predisposing to NPC; 2. more difference between CAR of the family and the control can be taken under this culture condition.