卵巢恶性肿瘤及输卵管癌患者血清唾液酸水平的临床意义

本文对103例卵巢恶性肿瘤及输卵管癌患者,35例子宫颈癌及子宫体癌和75例妇科良性疾病患者,539例健康成人,进行了1753次血清唾液酸水平检测。结果表明卵巢恶性肿瘤患者血清唾液酸水平(75.02±14.08mg/dl)明显高于健康成人组(54.72±5.83mg/dl),和妇科良性疾患组(58.50±9.08mg/dl),同时也高于子宫颈癌和子宫体癌组,经统计学处理均有显著差异(P<0.001)。对57例不同类型卵巢恶性肿瘤及输卵管癌患者进行治疗前,治疗中,治疗后血清唾液酸水平测定中发现,治疗前唾液酸值均在70mg/dl以上,治疗期间下降5～10mg/dl,治疗后获得缓解的病人,唾液酸值均降到正常范围52～60mg/dl,明显低于治疗前,统计学意义非常显著(P<0.01)。而未获缓解和恶化的患者唾液酸值上升到76～87mg/dl与治疗前相比没有统计学意义(P>0.05)。治疗期间血清唾液酸水平的动态检查与病情的变化有显著的相关性。故血清唾液酸的测定,不仅有助于卵巢良恶性疾患的鉴别诊断,同时对卵巢恶性肿瘤疗效的观察也有一定的参考价值。

CLINICAL SIGNIIFICANCE ON SERUM SIALIC ACID LEVEL IN OVARAN AND OVIDUCT CARCINOMA

Scrum sialic acid level was determined in 133 patients with gynecalogic carcinoma, 75 non-cancerous patients and 539 normal individuals. The results showed that serum sialic acid level was significantly higher in 103 ovarian carcinoma patients than that of the normal controls (P<0.001)，and it was also higher than that of the cerig carcinoma and noncancerous patients (P<0. 001) . Meaanwhile, 62 patients with ovarial and oviduct carc inoma were determined during treatment, among them siailc acid level appeared to decline in 43 patients of clinical remission, and to elevate in 19 patients of clinical nonchanged (P<0.01)，A positiv0 correlation was noticed between the sialic acid changed and the patients Who respnnscd to the treatment, Therefore, it is useful to determination serum sialic acid for diagnosing of ovarian carcinoma and observing curative effects.