口服抗病毒药物对慢性乙型肝炎患者肝纤维化的影响

目的:探讨采取瞬时弹性成像技术(TE)评估长期口服抗病毒药物对慢性乙型肝炎患者的肝脏硬度(LSM)变化及临床价值。方法:采用前瞻性研究方法,分析2010年1月-2012年12月收治的口服抗病毒药物治疗的慢性乙型肝炎患者60例的临床资料。结果:60例慢性乙型肝炎患者的平均治疗时间间隔为(325.6±124.1)d,治疗后的LSM显著低于治疗前[(10.3±6.1)kPa vs(17.2±11.5)kPa,P0.001],治疗后LSM改善的患者有32例(53.3%)。结论:长期口服抗病毒药物可有效改善慢性乙型肝炎患者的肝纤维化,TE是评估慢性乙型肝炎患者疾病进展的有用临床工具之一。

The Effect of Liver Fibrosis on Patients with Chronic Hepatitis B Treated by Oral Antiviral Drug

Objective： To explore the liver stiffness measurement （LSM） change and clinical value of patients with chronic hepatitis B treated by long-term oral antiviral drug assessed by taking transient elastography technique （TE）. Methods： The clinical data of 60 patients with chronic hepatitis B treated by long-term oral antiviral drug were studied and analyzed prospectively from Jan 2010 to Dec 2012. Results： Among the 60 cases, the average treatment time interval was （325.6±124.1 ） days, the LSM after the treatment was significantly lower than that in before the treatment [ （10.3±6.1） kPa vs （17.2±11.5）kPa, P〈0.001 ], and the LSM in 32 cases （53.3%） were improved after the treatment. Conclusion： The treatment of long-term oral antiviral can improve effectively liver fibrosis of chronic hepatitis B,TE is one of a useful clinical tool to assess progression of patients with chronic hepatitis B.