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急性冠脉综合征患者血清高密度脂蛋白胆固醇、超氧化物歧化酶、游离脂肪酸水平分析
引用本文:周楠,包金兰,黄灿霞,蒋捷羽,孙润陆,张玉玲.急性冠脉综合征患者血清高密度脂蛋白胆固醇、超氧化物歧化酶、游离脂肪酸水平分析[J].岭南急诊医学杂志,2014(2):81-82,85.
作者姓名:周楠  包金兰  黄灿霞  蒋捷羽  孙润陆  张玉玲
作者单位:中山大学孙逸仙纪念医院心内科,510120
基金项目:基金资助:国家自然科学基金(81070182)、广东省自然科学基金(10151008901000224)
摘    要:目的:探讨高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、游离脂肪酸(NEFA)水平与急性冠脉综合征(ACS)的相关性。方法:选择384例ACS患者为研究组,并选择同期住院的冠状动脉造影示无冠状动脉狭窄的285例非冠心病患者作为对照组,比较两组患者的HDL-C、SOD、NEFA。结果:与对照组比较,研究组HDL-C和SOD水平显著降低(P0.001),NEFA水平显著升高(JP0.001);研究组中HDL-C、SOD、NEFA水平均与冠状动脉病变严重程度相关。结论:ACS患者的冠脉病变严重程度和心肌坏死的进展与HDL-C、SOD、NEFA水平密切相关;HDL-C、SOD、NEFA水平的高低可作为预测心肌进一步损伤的重要指标,对冠心病的防治提供重要的临床依据。

关 键 词:高密度脂蛋白胆固醇  超氧化物歧化酶  游离脂肪酸  急性冠脉综合征

Analysis of Serum High Density Lipoprotein Cholesterol,Super Oxide Dismutase,Non-esterified Fatty Acid Levels in Patients with Acute Coronary Syndrome
ZHOU Nan,BAO Jin-lan,HUANG Can-xia,JIANG Jie-yu,SUN Run-lu,ZHANG Yu-ling.Analysis of Serum High Density Lipoprotein Cholesterol,Super Oxide Dismutase,Non-esterified Fatty Acid Levels in Patients with Acute Coronary Syndrome[J].Lingnan Journal of Emergency Medicine,2014(2):81-82,85.
Authors:ZHOU Nan  BAO Jin-lan  HUANG Can-xia  JIANG Jie-yu  SUN Run-lu  ZHANG Yu-ling
Institution:(Department of Cardiology,Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou , 510120)
Abstract:Objective:To investigate the levels of high density lipoprotein cholesterol (HDL-C),super oxide dismutase(SOD) and non-esterified fatty acid(NEFA) in patients with acute coronary syndrome(ACS). Methods: A total of 384 patients with ACS diagnosed by coronary angiography were selected as research group , and 285 cases admitted to the hospital in the same period with normal coronary angiogram were selected as control group. The HDL-C,SOD and NEFA were compared between the two groups. Results: The levels of HDL-C and SOD in research group were significantly lower than those in control group(P < 0.001).The level of NEFA in research group was significantly higher than that in control group(P < 0.001). In research group, the levels of HDL-C ,SOD and NEFA were related to the severity of the coronary artery stenosis. Conclusion: There is a compact correlation between the severity of coronary artery disease and the progress of myocardial necrosis with the levels of HDL-C、SOD and NEFA in patients with ACS. The levels of HDL-C、SOD and NEFA can be the important indicators to predict the further damage of myocardial, they are provided important clinical evidence for prevention of coronary heart disease.
Keywords:high density lipoprotein cholesterol  super oxide dismutase  non-esterified fatty acid  acute coronary syndrome
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