手术高风险区颅内病变的伽玛刀治疗58例体会

背景与目的：位于脑十、松果体和丘脑区的颅内病变位置深在，又属于脑重要功能区，手术风险高，全切除难度大，且多为恶性，治疗较为棘手。本文结合我们的临床病例，探讨应用OUR-XGD旋转式伽玛刀治疗手术高风险区颅内病变的疗效。方法：回顾性分析我院近5年来58例经MRI影像证实的手术高风险区颅内病变的伽玛刀治疗临床资料。结果：松果体区5例，局部控制率84．0％，改善率13．5％，无效率2．5％。脑干区39例，局部控制率84．0％。，恶化率6％，死亡率10％。丘脑区14例，局部控制率71．43％，改善率14．28％，无效率7．14％，加重率7．14％。结论：OUR-XGD旋转式伽玛刀是治疗手术高风险区颅内病变又一种有效的方法，该方法安全、微创、可极大地保留脑功能，可达到对恶性病变可控制病灶、延长生存时间、提高生存质量的目的。

Gamma Knife Radiotherapy for Intracranial Lesions Deep-sited or Located in Functional Areas

BACKGROUND & OBJECTIVE: Intrarranial lesions deep-sited or located in functional areas are still challenge to neurosurgeons. This study was to investigate the efficacy of Gamma knife radiotherapy for intracranial lesions deep-sited or located in functional areas. METHODS: Fifty-six patients with intracranial lesions deep -sited or located in functional areas were treated with OUR -XOD rotating gamma knife in the past 5 years in our center were analyzed. RESULTS: For tumors in pineal region, the local control rate and ineffective rate were 66.67% and 33.33%, respectively. For tumors in brain stem, the local control rate, deterioration rate and rate of mortality were 79.48%, 12.8% and 7.69%, respectively. For tumors in thalamus. the local control rate, improvement rate, ineffective rate and deterioration rate were 71.43%, 14.28%, 7.14% and 7.14%, respectively. CONCLUSIONS: OUR-XGU rotating gamma knife is an effective and minimally invasive method to treat intracranial lesions deep-sited or located in functional areas.