| 急性放射性肺损伤肺组织EGFR表达及视黄酸对其影响 |
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| 引用本文： | 赵娜,赵玉霞,刘丹,陈延治,姚雷.急性放射性肺损伤肺组织EGFR表达及视黄酸对其影响[J].医学临床研究,2008,25(10):1729-1732. |
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| 作者姓名： | 赵娜 赵玉霞 刘丹 陈延治 姚雷 |
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| 作者单位： | 中国医科大学附属第一医院放疗科,辽宁,沈阳,110001 |
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| 摘 要： | 目的]研究通过视黄酸(RA)对大鼠急性放射性肺损伤的干预作用,阐明其对放射性肺损伤肺组织表皮生长因子受体(EGFR)表达的影响.方法]健康雄性Wistar大鼠80只随机分为4组:正常对照组(A组)、单纯给药组(B组)、单纯照射组(C组)和照射加给药组(D组),每组20只.C、D两组大鼠行6MV-X线15Gy全胸野照射,B、D两组大鼠给予20mg/(kg·d)RA制剂灌服.于照射后第1、2、4、8周取右肺组织行HE和Masson染色,免疫组化方法检测EGFR的表达.结果]HE和Masson染色提示照射后的1周始肺泡腔有炎性细胞渗出,继之间质水肿.4及8周出现肺泡腔变小甚至结构破坏,局部实变,肺间质出现胶原纤维;B组与A组比各时间段的病理变化无明显差别,但D组与C组比较大鼠肺炎和肺水肿减轻,肺组织胶原纤维量减少.EGFR免疫组化染色显示C组与A组相比在各时间段EGFR表达均明显增强(P<0.001),D组与C组比第4、8周EGFR表达明显减弱(P<0.001).结论]EGFR参与放射性肺损伤的发生、发展,而RA从蛋白质水平有效抑制EGFR表达,为治疗放射性肺损伤提供了实验依据.
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| 关 键 词： | 肺炎 辐射损伤 受体 表皮生长因子-尿抑胃素/分析 维甲酸/药理学 |
Protective Effect of Retinoic Acid on Acute Radiation-induced Lung Injury and the Expression of Epidermal Growth Factor Receptor |
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| ZHAO Na,ZHAO Yu-xia,LIU Dan,et al.Protective Effect of Retinoic Acid on Acute Radiation-induced Lung Injury and the Expression of Epidermal Growth Factor Receptor[J].Journal of Clinical Research,2008,25(10):1729-1732. |
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| Authors: | ZHAO Na ZHAO Yu-xia LIU Dan |
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| Institution: | ZHAO Na,ZHAO Yu-xia,LIU Dan,et al(Department of Radiation Oncology,First Affiliated Hospital of China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective] To investigate the intervention effect of retinoic acid(RA) on acute radiation-induced lung injury,then to illuminate that RA effects the expression of epidermal growth factor receptor(EGFR) in rat models.Methods] Eighty Wistar rats were randomly divided into four groups with 20 rats in each:control group(group A),RA treatment group(group B),radiation group(group C) and radiation combined with RA treatment group(group D).Rats in group C and D were radiated with 6MV-X ray linear accelerator at a... |
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| Keywords: | pneumonia radiation injuries receptors epidermal growth factor-urogastrone/AN tretinoin/PD |
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