Clinical prognostic analysis of 116 patients with primary intestinal non-Hodgkin lymphoma |
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Authors: | Hong-Feng Gou Jian Zang Ming Jiang Yu Yang Dan Cao Xin-Chuan Chen |
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Institution: | (1) Center of Medical Oncology, West China Hospital, Sichuan University, Chengdu, China;(2) Department of Hematology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang St, 610041 Chengdu, Sichuan Province, China |
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Abstract: | The gastrointestinal tract is the most common extranodal invasion site of non-Hodgkin lymphoma (NHL). Primary gastrointestinal
NHL is often discussed together in most survival analyses. Primary intestinal NHL is significantly different from primary
gastric NHL with regard to clinical features, pathological subtype, treatment, and prognosis. In this article, we analyzed
clinical and pathological characteristics of primary intestinal NHL, and we also explored prognostic factors for primary intestinal
NHL. A retrospective analysis was carried out on clinical data from 116 cases of confirmed primary intestinal NHL. The Kaplan–Meier
method was used for the survival analysis. A Cox model was used for a multivariate analysis. In 116 patients with primary
intestinal NHL, 79 patients were men (68.1%) and 37 patients were women (31.9%). In the cases used in this study, 68 were
B-cell NHL and 48 were T-cell NHL. The age, incidence of intestinal obstruction, B symptom and performance status (PS) were
closely related with pathological subtype. One-year and two-year survival rates were 76.7 and 58.3%, respectively. The log-rank
univariate analysis showed male patients, PS score greater than or equal to two, hypoproteinemia, intestinal perforation,
T-cell type, late stage (III/IV), no radical surgery, and no chemotherapy had relatively poor prognoses. Cox multivariate
analysis shown that gender (95.0% CI 0.218–0.721), pathological subtype (95.0% CI 1.484–4.179), and radical surgery (95.0%
CI 0.110–0.394) were independent prognostic risk factor for primary intestinal NHL. Male patients, T-cell intestinal lymphoma,
and no radical surgery had rapid clinical processes and poor prognoses. |
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