Metabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice |
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Authors: | B Hedtke Z Gao L-J Chen W M Weber K J Dix |
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Institution: | Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA |
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Abstract: | The metabolism and disposition of 14C]5-amino-o-cresol (AOC) in female F344 rats following oral, intravenous, and dermal administration and in female B6C3F1 mice following oral administration were studied. Greater than 80% of a single oral dose (4.0–357 mg kg?1) or intravenous dose (2.7 mg kg?1) was excreted in urine within 24 h. When the dosing site was protected from grooming, less than 10% of the dermal dose (2.5 and 26 mg kg?1, rinsed off after 6 h) was absorbed within 24 h, and most of the absorbed radioactivity was excreted in urine. For the unprotected dermal dose, grooming played a major role in the absorption of AOC. Very little AOC-derived radioactivity was present in the surveyed tissues after 24 or 72 h regardless of route, dose level, or species. Five urinary metabolites were identified: 5-acetamido-1,4-dihydroxy-2-methylbenzene glucuronide, AOC O-glucuronide, AOC O-sulfate, N-acetyl-AOC O-glucuronide, and N-acetyl-AOC O-sulfate. |
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Keywords: | 5-Amino-o-cresol metabolism and disposition aromatic amines |
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