多学科诊疗模式用于肝胆恶性肿瘤的精准及免疫治疗的实践及思考

抗肿瘤治疗在近十年得到了显著进展,但肝脏及胆道恶性肿瘤的死亡率仍居高不下。肝胆恶性肿瘤作为高度异质性的疾病,其临床背景、病理表型及生物学特征复杂多样,需要"精分"、"精治"。以个体化诊疗为主要模式的精准医疗在肝胆恶性肿瘤亟待更多临床实践,同时,将肿瘤免疫治疗更加精准化是临床运用的主要发展方向,这就要求临床医师更多探索以多学科诊疗为主要手段的肝胆恶性肿瘤的精准及免疫治疗模式,构建以运用前沿诊疗技术手段、以临床问题为导向的多学科诊疗团队。

Application of multidisciplinary team in precision oncology and immunotherapy for hepatobiliary malignancies

The strategies for treating cancers have achieved significant progress in the past decade, while the mortality rate of hepatobiliary malignancies remains high.Hepatobiliary malignancies are featured as the diseases with abundant heterogeneity that are varied in clinic backgrounds, pathological phenotypes and biological characteristics, which need more precise in classification and clinical therapy.Precision medicine for hepatobiliary malignancies, based on personalized diagnosis and treatment requires more clinical practices.Meanwhile, the precision immunotherapy is the major direction for the development of clinical application, so that it is crucial for clinicians to construct a multidisciplinary team using cutting-edge diagnostic and therapeutic techniques and guided by clinical problems to explore the precision oncology and immunotherapy models of in patients with hepatobiliary malignancies.