某综合医院多重耐药菌感染目标性监测与综合干预研究

目的了解某综合医院住院患者多重耐药菌(MDRO)感染情况,采取有效的综合干预措施,以期降低医院MDRO感染。方法对2012年10月—2013年12月住院患者开展MDRO目标性监测,采取综合干预措施,比较干预前后MDRO医院感染发生情况。结果共调查住院患者62 384例,病原学送检率为17.91%(11 176例),606例次患者检出MDRO,其中MDRO医院感染292例次(0.47%),社区感染/定植314例次。MDRO医院感染例次率由干预前的0.65%(75/11 603),降至干预后的0.26%(36/13 875),差异具有统计学意义(χ2=21.08,P0.05)。结论采取综合干预措施可有效控制MDRO医院感染。

Targeted monitor and comprehensive intervention of multidrug resistant organism infection in a general hospital

ObjectiveTo evaluate the occurrence of multidrug resistant organism (MDRO) infection in a general hospital, and take effective comprehensive intervention measures, so as to reduce MDRO infection.MethodsTargeted monitoring on MDROs was performed from October 2012 to December 2013, comprehensive intervention measures were conducted, the occurrence of MDRO infection before and after intervention was compared.ResultsA total of 62 384 patients were investigated, 17.91%（n=11 176）were sent specimens for pathogen culture, 606 times of culture for patients’ specimens were detected MDROs, 292(0.47%) cases were MDRO healthcare associated infection(HAI)，314 were community acquired infection or colonization. MDRO infection case rate decreased from 0.65%（75/11 603） before intervention to 0.26%（36/13 875）after intervention (χ2=21.08，P＜0.05）.ConclusionComprehensive intervention measures can effectively reduce the occurrence of MDRO HAI.