| 肺癌患者肺部感染病原菌情况及血清CA153、CEA等相关因子水平检测分析 |
| |
| 引用本文： | 易金远,陈宏明,罗世官,农峰,覃雪梅.肺癌患者肺部感染病原菌情况及血清CA153、CEA等相关因子水平检测分析[J].中国病原生物学杂志,2019(3):354-357. |
| |
| 作者姓名： | 易金远 陈宏明 罗世官 农峰 覃雪梅 |
| |
| 作者单位： | 右江民族医学院附属医院胸心血管外科;右江民族医学院附属医院呼吸内科 |
| |
| 基金项目： | 广西医药卫生科研课题(No.Z2011143);广西高校桂西地区高发病防治研究重点实验室开放课题(右医科字2015 [2]号) |
| |
| 摘 要： | 目的分析肺癌患者肺部病原菌感染情况及患者血清中相关肿瘤标志物水平变化,并探讨其临床意义。方法 2015年7月-2018年1月本院收治的肺癌伴肺部感染患者80例(为感染组),同期入院的无肺癌伴肺部感染患者80例(为对照组)。采集感染组患者痰标本,采用全自动细菌鉴定仪检测病原菌种类及分布情况;采集患者血标本,采用全自动化学发光免疫分析仪检测比较两组患者血清中糖类抗原-153(carbohydrate antigen-153,CA153)、糖类抗原-199(carbohydrate antigen-199,CA199)及癌胚抗原(carcinoembryonic antigen,CEA)水平,分析其与肺癌癌症类型及分期的关系。结果 80例肺癌伴肺部感染患者共分离出病原菌118株。包括革兰阴性菌71株(占60.17%)、革兰阳性菌35株(占29.67%)、真菌12株(占10.17%)。感染组患者血清中CA153、CA199及CEA水平分别为(73.39±7.68) U/mL、(128.66±13.59) U/mL和(16.61±1.72) ng/mL,对照组分别为(7.24±0.63) U/mL、(8.62±1.07) U/mL和(2.12±0.24) ng/mL(t_1=76.782;t_2=78.761;t_3=74.627,P<0.05)。按组织类型分组,腺癌组患者血清中CA153、CA199及CEA水平显著高于小细胞癌组及鳞癌组(t1小=16.344;t2小=9.392;t3小=19.855;t1鳞=10.698;t2鳞=6.306;t3鳞=12.501,P<0.05)。对肺癌患者进行TNM分期,Ⅲ-Ⅳ期患者血清CA153、CA199及CEA水平显著高于Ⅰ-Ⅱ期(t_1=26.085;t_2=12.905;t_3=23.775,P<0.05)。结论肺癌患者肺部感染致病菌以革兰阴性菌占多数;患者血清中CA153、CA199及CEA水平升高,可作为肺癌的诊断指标,且对肺癌类型及癌细胞扩散、转移程度的判定有指导意义。
|
| 关 键 词： | 肺癌 肺部感染 病原菌 肿瘤标志物 |
Analysis of pathogens,serum CA153 and CEA,and other related factors in patients with lung cancer and a pulmonary infection |
| |
| YI Jin-yuan,CHEN Hong-ming,LUO Shi-guan,NONG Feng,QIN Xue-mei.Analysis of pathogens,serum CA153 and CEA,and other related factors in patients with lung cancer and a pulmonary infection[J].Journal of Pathogen Biology,2019(3):354-357. |
| |
| Authors: | YI Jin-yuan CHEN Hong-ming LUO Shi-guan NONG Feng QIN Xue-mei |
| |
| Institution: | (Thoracic and Cardiovascular Surgery;Respiratory Medicine,The Hospital Affiliated with Youjiang Medical College for Na-tionalities,Baise,Guangxi,China 533000) |
| |
| Abstract: | YI Jin-yuan;CHEN Hong-ming;LUO Shi-guan;NONG Feng;QIN Xue-mei(Thoracic and Cardiovascular Surgery;Respiratory Medicine,The Hospital Affiliated with Youjiang Medical College for Na-tionalities,Baise,Guangxi,China 533000) |
| |
| Keywords: | Lung cancer pulmonary infection pathogens tumor markers |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
